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Advances in Brain Stimulation - understanding and treating debilitating brain diseases

 Export to Your Calendar 2/6/2019
When: Feb 6, 2019
5:30-8:30 PM
Where: Regis College, Fine Arts Center
235 Wellesley St
Weston, Massachusetts  02493
United States
Contact: Bill Munger
617-620-4161


Online registration is available until: 2/6/2019
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Wed Feb 6 - MDG Boston FORUM
Advances in Brain Stimulation
Technological advances in minimally and non-invasive access to the brain, in imaging, in detection of brain electrical activity and in data analytics are creating new understanding of the brain, and of anatomic and functional brain disorders.  
 
Our speakers, who are at the forefront of this progress, will discuss both the technology and implications of these breakthroughs for understanding and treating debilitating brain diseases.
 
Program Description  

Recent breakthroughs in data analytics and AI are allowing new insights and treatments for the common brain disorders of mood, cognitive function and movement.  This progress results from researching previously inaccessible information contained in EEG and Magnetic Field signals which accompany the brain's electrical activity. 

Applied electric fields have been shown to alleviate depression, as in electric shock treatment, while application of Low Field Magnetic Stimulation (LFMS) is a promising electromagnetic treatment that addresses a range of mood and anxiety related symptoms.
 
Mike Rohan, PhD, Lecturer on Psychiatry at Harvard Medical School and physicist at McLean Hospital Imaging Center, will describe the use of Low Field Magnetic Stimulation (LFMS). an electromagnetic treatment for depression that addresses a range of mood and anxiety related symptoms. It is a series of low strength, high frequency, electromagnetic field pulses that produces rapid improvements in mood.

Ana Maiques, CEO of Neuroelectrics, will discuss how non-invasive brain stimulation can become a new at-home therapy for patients suffering from epilepsy or Alzheimer's disease. She will describe how to develop new business models to enable these new developments to reach patients at home for help when drugs are not providing adequate relief.  

Dr. Ron Alterman, Chief of Neurosurgery at the Beth-Israel Deaconess Medical Center, will discuss use of electric stimulation applied via advanced stereotactic surgical methods to exact sites within the brain for treatment of movement and psychiatric disorders.

Our session is moderated by Dr. Teo Dagi, neurosurgeon, investor, consultant and esteemed academic, and MDG Advisory Board Member.
 

 
 
 
Wednesday
Feb 6, 5:30 - 8:30 PM
Regis College Fine Arts Center
Weston, MA
 
MDG Boston Early Bird Forum Fees
 Member/Alliance Partner - $30   
   Non-member - $45 
   Student (member) - $10
   Student (non-member) - $15
Gold Member - No Charge
     
Event Sponsor
 
  Event Sponsorship - $500  
 (contact Hank Allard for details -hallard@mdgboston.org) 
 
We hope you can join us  
for this conversation 
 
Who Should Attend: 
  • Scientists and Engineers who are interested in how electric and magnetic fields can detect and alleviate thought, emotion and coordinated brain activity.
  • Caregivers interested in emerging concepts of how disease, thought and mood disorders can be better understood by data analytics for electromagnetic brain signals.
  • Managers and investors seeking opportunities in emerging CNS technology.
  • AI and data analytic professionals whose technology promises new insights into understanding brain function.
Our Distinguished Panel
 
Michael L Rohan, PhD
Physicist, McLean Hospital Imaging Center and Lecturer in Psychiatry, Harvard Medical School
Ana Maiques
CEO, Neuroelectrics
Ron L. Alterman, MD
Beth Israel Deaconess Medical Center, Chief, Division of Neurosurgery Harvard Medical School, Professor of Neurosurgery
Teo Dagi
General Partner, HLM Venture Partners Distinguished Scholar and Professor at the School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland Visiting Professor, Harvard Medical School
Panel Bios     
 
Michael L Rohan, PhD      
Physicist, McLean Hospital Imaging Center and Lecturer in Psychiatry, Harvard Medical School
After a career developing and producing the first fMRI systems at Advanced NMR Systems Inc. (1986-1999), Michael L. Rohan, came to McLean Hospital and Harvard Medical School. Here, as both a physicist and neuroscientist, he has developed Low Field Magnetic Stimulation (LFMS) from a hypothesis based on a clinical observation into a medical device that has been evaluated by the NIH as part of its RAPID program for fast acting antidepressants.

Abstract
Low Field Magnetic Stimulation (LFMS) is an electromagnetic treatment for depression that addresses a range of mood and anxiety related symptoms. It is a series of low strength (1 V/m), high frequency (91 kHz) electromagnetic field pulses that produces rapid improvements in mood. The low electric field strength and high frequency pulses employed by LFMS are different from those used in other electromagnetic treatments, as is the rapid clinical response that LFMS provokes - subjects report mood improvement within minutes, rather than within weeks. These differences suggest that LFMS is exploiting a novel mechanism for its effects on symptoms of depression and anxiety. The effects of LFMS on mood have been primarily observed in subjects with bipolar depression, although studies including subjects with major depression have demonstrated a similar response.

Ana Maiques
CEO, Neuroelectrics
Ana Maiques is the CEO of Neuroelectrics, a company aiming to change the way we interact with the brain, developing innovative technologies to monitor and stimulate the brain to help many patients in need. She was nominated by IESE as one of the most influential entrepreneurs under 40 in Spain (2010) and received the EU Prize for Women Innovators from the European Commission EC in 2014 and one of the Most Inspiring Fifty Women in Europe. Neuroelectrics recently received the Best Start-up in Health 2015 bye Wired UK magazine in an amazing event in London. She now lives in Boston where Neuroelectrics was awarded as one of the 2016 Best Entrepreneurial Companies in USA by Entrepreneur Magazine.

Abstract
Ana will describe new trends in digital therapeutics and how non-invasive brain stimulation can become a new at-home therapy for patients suffering from epilepsy or Alzheimer. She will describe how to develop new business models to make sure technologies reach patients' homes and help where drugs are not providing solutions to large populations in need. She will also provide a live demonstration of the Neuroelectrics device.

Ron L. Alterman, MD
Beth Israel Deaconess Medical Center, Chief, Division of Neurosurgery Harvard Medical School, Professor of Neurosurgery
Ron L. Alterman, M.D. is Professor of Neurosurgery at Harvard Medical School and Chief of the Division of Neurosurgery within the Roberta and Stephen R. Weiner Department of Surgery at Beth Israel Deaconess Medical Center (BIDMC). He specializes in Stereotactic Procedures for brain tumors, movement disorders, and psychiatric disorders

Dr. Alterman received his Bachelor of Arts magna cum laude from the University of Pennsylvania and his Medical Doctorate with distinction (AOA) from the Albert Einstein College of Medicine. He interned at Washington University in St. Louis, and completed his Neurosurgery Residency training at Montefiore Medical Center in New York and then joined the NYU Neurosurgery Faculty.

In 1998 he moved to New York's Beth Israel Medical Center where he established the busiest deep brain stimulation program in the New York Tri-State region. In 2002 he earned his M.B.A. with Honors from Columbia Business School. In 2003, he served at Walter Reed Army Hospital in Washington, DC in support of Operation Iraqi Freedom and was honorably discharged from the U.S. Army Reserve Medical Corps at the rank of lieutenant colonel in 2008.

Dr. Alterman became Chief of the Division of Neurosurgery at BIDMC in 2011. Under his leadership, BIDMC Neurosurgery has doubled its faculty and grown its clinical volume more than 50%. Centers of excellence have been established in Functional neurosurgery, Neuro-oncology, and Vascular/Endovascular Neurosurgery. Dr. Alterman has received numerous honors throughout his career, including the Young Neurosurgeon Award from the World Society for Stereotactic and Functional Neurosurgery.

 

Abstract

Over the last quarter century, various forms of Neural Stimulation have dramatically impacted the treatment of many neurological disorders including chronic pain, Parkinson’s disease, tremor, dystonia, epilepsy, obsessive compulsive disorder and depression. While these successes underscore the potential of neural stimulation to restore and even enhance human function, the field of neuromodulation is still nascent, its full impact on the human experience not nearly realized.

 

I will provide an overview of the field of neural stimulation, focusing on Deep Brain Stimulation (DBS), the most successful of these technologies to date, as a model. I will demonstrate the potential of the technology, even in its current rudimentary form, and discuss the technological and neurobiological obstacles to making neural stimulation even more effective and therefore more widely employed. I will also touch on competing technologies for modulating neural function and the ethical challenges our field faces as we move these technologies forward.

 
Teo Dagi - MODERATOR
General Partner, HLM Venture Partners Distinguished Scholar and Professor at the School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland Visiting Professor, Harvard Medical School
Teo received an AB Columbia, and an MD and MPH from Johns Hopkins. He trained in neurosurgery at the Massachusetts General Hospital and the Guy's, Maudsley and King's College Hospitals Neurosurgical Unit in London. He was appointed the Neuroresearch Foundation Fellow, and then the Joseph P. Kennedy, Jr., Fellow at Harvard University. Teo also received an MBA with distinction from Wharton and was awarded a DMedSc (Honoris Causae) from Queen's University for contributions to medicine and public service.

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